Tuberous Sclerosis-Complex (TSC) — A rare multisystem disease — Its Neuro-psychiatric manifestations

Blue ribbon- A recognized symbol of Tuberous Sclerosis Complex (TSC) : https://nationaltoday.com/

Tuberous Sclerosis Complex (TSC), a rare autosomal genetic and neurological condition, is also called as Bournville Disease. Apart from a range of neuropsychiatric conditions, Tuberous Sclerosis Complex (TSC) is typified by skin lesions, seizures, and brain, eyes, heart, lungs and kidney hamartomas. Hamaratoma is a benign tumor (non-cancerous) deformity composed of an aberrant mixing of cells. (A hamartoma in the hypothalamus of the brain can cause epileptic seizures.)

Brain lesions in Tuberous Sclerosis-Complex (source: https://ajronline.org/doi/10.2214/AJR.07.2928 )

According to reports, the prevalence of Tuberous Sclerosis Complex (TSC) was 6.8–12.4 per 100,000 people, with no gender-specific differences. At birth, the incidence of TSC is roughly 1 in 6,000. TSC affects several organs and is linked to a range of medical symptoms that appear with aging.

Because of its rarity, Tuberous Sclerosis Complex (TSC) is often misdiagnosed and maltreated even by most competent pediatricians and neurologists.

As Tuberous Sclerosis Complex (TSC) is a genetic disorder, the severity of TSC’s clinical manifestations may vary and exhibit varying symptoms between and…